ABSTRACT
Background: Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required. Aim: To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemo radiotherapy after curative resection of gastric adenocarcinoma. Material and methods: Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemo radiation. Survival analysis was based on the records and information from the National Mortality Registry. Results: Five years survival fluctuated from 50 percent among patients in stage IB to 25 percent among those is stage IV. Significant acute toxicity was observed in 23 patients (31 percent). No patients died due to acute toxicity. Eleven patients (16.4 percent) developed significant late toxicity, with two possible deaths related to treatment. Conclusions: Postoperative chemo radiotherapy is feasible in our experience. Continues infusion of 5-fluoruracil is recommended to reduce toxicity.
Subject(s)
Adult , Aged , Humans , Middle Aged , Young Adult , Adenocarcinoma/therapy , Stomach Neoplasms/therapy , Adenocarcinoma/mortality , Chemotherapy, Adjuvant/adverse effects , Disease-Free Survival , Neoplasm Staging , Radiotherapy, Adjuvant/adverse effects , Retrospective Studies , Stomach Neoplasms/mortality , Survival Analysis , Treatment Outcome , Young AdultABSTRACT
Se analiza 10 casos de pacientes portadores de tumores localizados en faringolaringe y esófago cervical que fueron operados y reconstruidos con un colgajo miocutáneo pectoral mayor en forma primaria. En todos estos casos no fue posible usar la mucosa faringoesofágica para cerrar en forma primaria debido a la extensión tumoral. La morbilidad fue de un 10%y la mortalidad de un 20%. En 7 casos se obtuvo una buena restitución de la alimentación oral. La técnica se considera para lesiones faringoesofágicas y en pacientes de alto riesgo quirúrgico
Subject(s)
Esophageal Neoplasms/surgery , Laryngeal Neoplasms/surgery , Pharyngeal Neoplasms/surgery , Surgical Procedures, Operative/rehabilitation , Esophageal Neoplasms/radiotherapy , Laryngeal Neoplasms/radiotherapy , Pharyngeal Neoplasms/radiotherapyABSTRACT
Se presenta una paciente de 70 años de edad con carcinoma neuroendocrino de la piel extenso localizado en la región cigomática. El diagnóstico preciso es efectuado combinando parámetros clínicos, histológicos y tinción de inmunoperoxidasa para la búsqueda de enolasa neuroespecífica y cromogranina. El tratamiento elegido fue biasociado consistente en radioterapia y quimioterapia. Se revisa de la literatura aspectos clínicos, diagnósticos y tratamiento